Introduction. A comparative study of the phenotypic manifestations of undifferentiated connective tissue dysplasia in children of various age groups with urological and andrological pathology is carried out in the article. Materials and methods. The study included 214 children aged 1 month to 17 years with clinical manifestations of undifferentiated connective tissue dysplasia, who were treated in the pediatric uroandrological department for congenital malformations and diseases of the genitourinary system. When establishing undifferentiated connective tissue dysplasia, a generally accepted table of external phenotypic markers was used with their scores. Results. In infants, abnormalities of the auricles and skin are most often detected. In pre-school age, craniocephalic abnormalities, pathology of the osteoarticular system, and abnormalities of the auricles were detected in the largest percentage of cases. The study found that an increase in the percentage of detection of ocular abnormalities increases with age. Moreover, 2 or more eye abnormalities were most common in older children. Anomalies of the oral cavity were diagnosed in only a quarter of infants and were manifested in them by a single sign. In older age categories, anomalies of the oral cavity were observed in more than half of patients, and often they were not single. During the examination of senior schoolchildren, it was noted that all children of this age category had some kind of abnormality from the osteoarticular system, and almost always they were multiple. Conclusion. Somatic manifestations of undifferentiated connective tissue dysplasia are often multi-organ in nature and often have nonspecific clinical symptoms. Identification of the patterns of formation of uroandrological pathology in patients of various age groups against the background of connective tissue failure will provide timely prevention and correction of visceral manifestations of dysplasia in children.
| Published in | International Journal of Clinical Urology (Volume 5, Issue 1) |
| DOI | 10.11648/j.ijcu.20210501.13 |
| Page(s) | 10-15 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Children, Dysplasia, Connective Tissue, Phenotypic Signs, Uroandrological Diseases
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APA Style
Sharkov Sergey Mikhailovich, Vasilyeva Irina Germanovna, Safronov Boris Grigorievich. (2021). Dynamics of Phenotypic Manifestations of Connective Tissue Dysplasia in Children with Uroandrological Pathology in the Age Aspect. International Journal of Clinical Urology, 5(1), 10-15. https://doi.org/10.11648/j.ijcu.20210501.13
ACS Style
Sharkov Sergey Mikhailovich; Vasilyeva Irina Germanovna; Safronov Boris Grigorievich. Dynamics of Phenotypic Manifestations of Connective Tissue Dysplasia in Children with Uroandrological Pathology in the Age Aspect. Int. J. Clin. Urol. 2021, 5(1), 10-15. doi: 10.11648/j.ijcu.20210501.13
AMA Style
Sharkov Sergey Mikhailovich, Vasilyeva Irina Germanovna, Safronov Boris Grigorievich. Dynamics of Phenotypic Manifestations of Connective Tissue Dysplasia in Children with Uroandrological Pathology in the Age Aspect. Int J Clin Urol. 2021;5(1):10-15. doi: 10.11648/j.ijcu.20210501.13
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Download@article{10.11648/j.ijcu.20210501.13,
author = {Sharkov Sergey Mikhailovich and Vasilyeva Irina Germanovna and Safronov Boris Grigorievich},
title = {Dynamics of Phenotypic Manifestations of Connective Tissue Dysplasia in Children with Uroandrological Pathology in the Age Aspect},
journal = {International Journal of Clinical Urology},
volume = {5},
number = {1},
pages = {10-15},
doi = {10.11648/j.ijcu.20210501.13},
url = {https://doi.org/10.11648/j.ijcu.20210501.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20210501.13},
abstract = {Introduction. A comparative study of the phenotypic manifestations of undifferentiated connective tissue dysplasia in children of various age groups with urological and andrological pathology is carried out in the article. Materials and methods. The study included 214 children aged 1 month to 17 years with clinical manifestations of undifferentiated connective tissue dysplasia, who were treated in the pediatric uroandrological department for congenital malformations and diseases of the genitourinary system. When establishing undifferentiated connective tissue dysplasia, a generally accepted table of external phenotypic markers was used with their scores. Results. In infants, abnormalities of the auricles and skin are most often detected. In pre-school age, craniocephalic abnormalities, pathology of the osteoarticular system, and abnormalities of the auricles were detected in the largest percentage of cases. The study found that an increase in the percentage of detection of ocular abnormalities increases with age. Moreover, 2 or more eye abnormalities were most common in older children. Anomalies of the oral cavity were diagnosed in only a quarter of infants and were manifested in them by a single sign. In older age categories, anomalies of the oral cavity were observed in more than half of patients, and often they were not single. During the examination of senior schoolchildren, it was noted that all children of this age category had some kind of abnormality from the osteoarticular system, and almost always they were multiple. Conclusion. Somatic manifestations of undifferentiated connective tissue dysplasia are often multi-organ in nature and often have nonspecific clinical symptoms. Identification of the patterns of formation of uroandrological pathology in patients of various age groups against the background of connective tissue failure will provide timely prevention and correction of visceral manifestations of dysplasia in children.},
year = {2021}
}
TY - JOUR T1 - Dynamics of Phenotypic Manifestations of Connective Tissue Dysplasia in Children with Uroandrological Pathology in the Age Aspect AU - Sharkov Sergey Mikhailovich AU - Vasilyeva Irina Germanovna AU - Safronov Boris Grigorievich Y1 - 2021/01/28 PY - 2021 N1 - https://doi.org/10.11648/j.ijcu.20210501.13 DO - 10.11648/j.ijcu.20210501.13 T2 - International Journal of Clinical Urology JF - International Journal of Clinical Urology JO - International Journal of Clinical Urology SP - 10 EP - 15 PB - Science Publishing Group SN - 2640-1355 UR - https://doi.org/10.11648/j.ijcu.20210501.13 AB - Introduction. A comparative study of the phenotypic manifestations of undifferentiated connective tissue dysplasia in children of various age groups with urological and andrological pathology is carried out in the article. Materials and methods. The study included 214 children aged 1 month to 17 years with clinical manifestations of undifferentiated connective tissue dysplasia, who were treated in the pediatric uroandrological department for congenital malformations and diseases of the genitourinary system. When establishing undifferentiated connective tissue dysplasia, a generally accepted table of external phenotypic markers was used with their scores. Results. In infants, abnormalities of the auricles and skin are most often detected. In pre-school age, craniocephalic abnormalities, pathology of the osteoarticular system, and abnormalities of the auricles were detected in the largest percentage of cases. The study found that an increase in the percentage of detection of ocular abnormalities increases with age. Moreover, 2 or more eye abnormalities were most common in older children. Anomalies of the oral cavity were diagnosed in only a quarter of infants and were manifested in them by a single sign. In older age categories, anomalies of the oral cavity were observed in more than half of patients, and often they were not single. During the examination of senior schoolchildren, it was noted that all children of this age category had some kind of abnormality from the osteoarticular system, and almost always they were multiple. Conclusion. Somatic manifestations of undifferentiated connective tissue dysplasia are often multi-organ in nature and often have nonspecific clinical symptoms. Identification of the patterns of formation of uroandrological pathology in patients of various age groups against the background of connective tissue failure will provide timely prevention and correction of visceral manifestations of dysplasia in children. VL - 5 IS - 1 ER -
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