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Preliminary Metabolomic Study of Urine Samples in Patients Affected by Renal Clear Cell Cancer by GC-MS
Massimo Madonia,
Antonio Murgia,
Gianmarco Garau,
Bruno Bussa,
Pierluigi Caboni
Issue:
Volume 2, Issue 1, June 2018
Pages:
1-5
Received:
17 May 2018
Accepted:
12 June 2018
Published:
6 July 2018
Abstract: Renal cell carcinoma (RCC) represent 2-3% of all cancers. Currently, there are no invasive screening tests that could help to find diagnosis and possible follow up in clinical practice. Most renal tumors are diagnosed by abdominal ultrasound (US) or contrast-enhanced (CT) performed for other medical reasons. In this work, the metabolite profile of urine of RCC samples, has been studied by gas chromatography coupled to mass spectrometry (GC-MS) and multivariate statistical data analysis. By the same means, differences between pathological and control samples were investigated. Results of discriminant analysis were studied with the aim to find possible relevant metabolites for each class. Palmitic acid, malic acid, allo-inositol, oleic acid and aspartic acid were up-regulated in pathological samples while psicose was down-regulated.
Abstract: Renal cell carcinoma (RCC) represent 2-3% of all cancers. Currently, there are no invasive screening tests that could help to find diagnosis and possible follow up in clinical practice. Most renal tumors are diagnosed by abdominal ultrasound (US) or contrast-enhanced (CT) performed for other medical reasons. In this work, the metabolite profile of ...
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Perspectives of Plasmapheresis in the Treatment of Kidney Diseases
Valerii Alexandrovich Voinov,
Konstantin Stepanovich Karchevsky,
Oleg Valerievich Isaulov
Issue:
Volume 2, Issue 1, June 2018
Pages:
6-14
Received:
30 May 2018
Accepted:
22 June 2018
Published:
21 July 2018
Abstract: Many kidney diseases pose a serious threat to human health and even life. In some cases, they inevitably lead to hemodialysis and even the need for kidney transplantation. Almost all chronic kidney disease in varying degrees, are associated with disorders of the internal environment, mainly autoimmune nature. Drug therapy is not always effective and can lead to additional disorders. Pathogenetically justified is the use of plasmapheresis. The aim of this study was to analyze the modern world literature in order to identify the features of the pathogenesis and course of various forms of chronic kidney disease in terms of determining the possibility of using plasmapheresis and indications for it. With the help of plasmapheresis, a number of problems can be solved in urology, in particular in the treatment of pyelonephritis, prostatitis and even male infertility.
Abstract: Many kidney diseases pose a serious threat to human health and even life. In some cases, they inevitably lead to hemodialysis and even the need for kidney transplantation. Almost all chronic kidney disease in varying degrees, are associated with disorders of the internal environment, mainly autoimmune nature. Drug therapy is not always effective an...
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Erectile Dysfunction: Prevalence, Characteristics and Etiological Factors Among Urology Outpatients in Burkina Faso
Fasnéwindé Aristide Kaboré,
Boureima Ouédraogo,
Bienvenue Désiré Ky,
Clotaire Alexis Marie Kiemdiba Donega Yameogo,
Brahima Kirakoya,
Kambou Timothée
Issue:
Volume 2, Issue 1, June 2018
Pages:
15-19
Received:
17 June 2018
Accepted:
20 July 2018
Published:
24 August 2018
Abstract: The erectile dysfunction (ED) is the inability to get or maintain an erection for a satisfied intercourse. This can affect the patient's life with an impact on his partner life and their relationship. We had conducted a transversal descriptive and analytical study based on prospective data's during a period of six month time (January 1st to June 30th). The sample population were Yalgado Ouedraogo University medical center male outpatient aged 18 year and up from the urology-andrology department. The evaluation of the ED was done by using a self survey form of the International Index of the Erectile Function simplified in five questions (IIEF5). A total of 440 patients, 410 had and exploited survey. The average age of the included patients was 52.4 +/- 14.1 (the extremes were 24 and 68 years old). 111 patients had an ED with a prevalence of 27%. The average age who had an ED was 48.2 +/-11.9 years old. The ED by age prevalence showed an progressive increase with age. The ED is frequent in our hospital urology department. This concerns almost 1/3 of our department patients. Its occurence and severity are influenced by its length, the age, the smokes, the obesity, the cardiovascular diseases, and the SBAU.
Abstract: The erectile dysfunction (ED) is the inability to get or maintain an erection for a satisfied intercourse. This can affect the patient's life with an impact on his partner life and their relationship. We had conducted a transversal descriptive and analytical study based on prospective data's during a period of six month time (January 1st to June 30...
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Anatomical and Functional Results of Pelvic Organ Prolapse Mesh Repair: A Prospective Study of 105 Cases
Vigen Malkhasyan,
Malika Dzhuraeva,
George Kasyan,
Dmitry Pushkar
Issue:
Volume 2, Issue 1, June 2018
Pages:
20-24
Received:
17 July 2018
Accepted:
10 August 2018
Published:
12 September 2018
Abstract: Objective: We assess the anatomical and functional results of pelvic organ prolapse (POP) repair with application of transvaginal synthetic meshes. Keywords: pelvic organ prolapse, vaginal repair, urogynecology. Methods: We analyzed a cohort of 105 women who underwent transvaginal pelvic floor repair using mesh (Elevate Prolapse Repair System). A gynecological examination, cough test, uroflowmetry and an administration of the overactive bladder Awareness Tool were done. Parametric and nonparametric methods of descriptive statistics, as well as logistic regression were used for data analysis. Results: Prolapse recurrence after vaginal repair was noted in 3.81% (n=4) of patients. The proportion of patients with de novo onset of incontinence after surgery was 8.57% (n=9). In 26.7% (n=28) of women with stress urinary incontinence (SUI), SUI symptoms persisted after surgery. The mean Qmax in the patient group was 19.5 ml/s. The mean Qmax in patients reporting bladder-emptying problems was 14 ml/s, and the mean post-void residual (PVR) was 50±15.0 ml. After surgery, the mean Qmax increased to 27.6 ml/s. The PVR after surgery decreased to 30±5.0 ml. The number of patients with bladder outlet obstruction symptoms decreased to 17 (16.19%). Conclusion: The management of genital prolapse with synthetic prostheses interposed through vaginal approach is an efficient method with good midterm outcomes.
Abstract: Objective: We assess the anatomical and functional results of pelvic organ prolapse (POP) repair with application of transvaginal synthetic meshes. Keywords: pelvic organ prolapse, vaginal repair, urogynecology. Methods: We analyzed a cohort of 105 women who underwent transvaginal pelvic floor repair using mesh (Elevate Prolapse Repair System). A g...
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